Online Dermatologist > Keratoacanthoma

Medically reviewed by The Dermatologists and written by Dr. Alexander Börve

Last updated on May 14, 2024

Keratoacanthoma (KA) on the stomach showing a small, dome-shaped, pinkish-red lesion, indicative of a rapidly growing skin tumor (ICD-10 L85.8)

A keratoacanthoma is a skin tumor caused by overexposure to the sun in older adults. The differential diagnosis is squamous cell carcinoma and is always treated the same way by a doctor. The tumor grows quickly, but unlike cancer, it usually does not spread to other parts of the body by way of the blood or lymphatic vessels or membranous surfaces.

Trauma, ultraviolet light, chemical carcinogens, human papillomavirus (HPV), genetic factors, and immunocompromised status may trigger keratoacanthoma.

It is rare in people younger than 20 years old, and the risk increases significantly after the age of 64. Men are twice as likely to contract the disease, and is less common in darker-skinned individuals.

Symptoms

Keratoacanthoma usually appears on the face, forearms, and hands. It often occurs at site of excessive sun exposure or previous injury or trauma. The lesion is dome-shaped and scaly, while the surrounding skin is smooth but inflamed.

Keratoacanthoma (KA) on the back showing a small, red, dome-shaped lesion with a central crust, or plug of keratin, which is a hallmark feature

Keratoacanthoma and squamous cell carcinoma have similar features, such as actinic damage.

The lesion starts as a small, round, flesh-colored or red bump, and then grows rapidly on the skin from 1-2mm to 1-3cm over a few weeks. Then, it becomes a smooth dome-shaped lesion with a central core. It stops growing after 6-8 weeks and remains unchanged for 2-6 weeks.

Keratoacanthoma (KA) located on the eyebrow. It shows a large, dome-shaped lesion with a central crust, consistent with the later stages of KA development

If the core of brown keratin (the material of which hair and the outermost layer of skin is made) comes out, a crate remains. This makes the lesion look like a “mini-volcano.”

Keratoacanthoma on the trunk, characterized by a pinkish-red, raised lesion with a central crust or core. When the core of brown keratin comes out, it leaves a crater, making the lesion resemble a “mini-volcano.

The self-healing process then begins. Over the subsequent 2-12 months, it spontaneously regresses and flattens and eventually leaves a scar.

What can I do?

Monitor the lesion and seek medical advice if you see any change in size, color or appearance. Make sure to prevent exposure to the sun. Use broad spectrum sunscreen of SPF 30+ and cover yourself up.

Should I seek medical care?

Although the tumor is benign and usually heals on its own, they can sometimes develop into squamous cell carcinoma if left untreated. You also need a healthcare professional to determine if it is a cancerous growth instead.

Treatment

Surgical excision can remove the growth if it does not die and heal on its own. Excision is also needed for a biopsy. Other methods include electrodesiccation and curettage, podophyllin resin, methotrexate intralesional injections, and radiotherapy.

Topical 5-fluorouracil cream applied three times a day for 1 to 6 weeks has been found to be effective. Oral isotretinoin and oral acitretin are also useful if you have multiple growths.

Source:
American Osteopathic College of Dermatology. Keratoacanthoma. Available at: https://www.aocd.org/?page=Keratoacanthoma

British Association of Dermatologists. Keratoacanthoma. Available at: https://www.bad.org.uk/shared/get-file.ashx?id=96&itemtype=document

Tsu-Yi Chuang, MD, MPH, FAAD. Keratoacanthoma. Medscape. Available at: https://emedicine.medscape.com/article/1100471-overview#a5